A new trailer and key visual were revealed for the Trigun Stampede anime at the Lock ‘n Load Panel at Anime Expo on July 2, 2022.
The cast for the main characters of the anime were also revealed in the trailer and the official website.

The key cast members include:
- Yoshitsugu Matsuoka as Vash the Stampede
- Junya Ikeda as Millions Knives
- Maaya Sakamoto as Rem Saverem
Additionally, Tomoyo Kurosawa and Yumiri Hanamori will be voicing the younger version of Vash and Knives respectively.
Orange studio is in charge of animating Trigun Stampede. The key staff announced include:
- Director: Kenji Muto
- Concept Design, Character Concept: Kouji Tajima
It was earlier announced that the anime will release in 2023.
Crunchyroll will be simulcasting the anime in North America, Central America, South America, Europe, Africa, Oceania, the Middle East, CIS, the Philippines, Singapore, India, Pakistan, Bhutan, Sri Lanka, Bangladesh, Nepal.
The original Trigun manga ran from 1995 to 1997 and was published by Monthly Shonen Champion. The sequel ran from 1997 to 2007 and was published by Young King OURS. Dark Horse released the English edition of the manga in North America.
An anime adaptation of the manga aired in 1998 and was produced by Madhouse.
Source: Official website of Trigun.
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